Table 3.

Common Strategies of Targeting Biomaterial Vectors for Gene Delivery to the CNS.

Mode of Targeting	Key Examples	Receptor	Location	References
Protein
	Transferrin	Transferrin receptor	BBB	(Cardoso et al., 2010; da Cruz et al., 2005; Huang et al., 2007; Sharma et al., 2013; Somani et al., 2014)
	Lactoferrin	Lactoferrin receptor	BBB	(Chen et al., 2010; Huang et al., 2010a, 2010b, 2009, 2008)
	Neurotensin	Neurotensin receptor	Neurons	(Gonzalez-Barrios et al., 2006; Hernandez-Chan et al., 2015)
	Angiopep	Low-density lipoprotein receptor	BBB & Glioma	(An et al., 2015; Gao et al., 2016; Huang et al., 2013; Ke et al., 2009; Sun et al., 2012)
Antibody
	Anti-Transferrin Receptor Monoclonal Antibody	Transferrin receptor	BBB	(Ko et al., 2009; Kolhar et al., 2013; Zhang et al., 2003, 2004)
Viral Glycoprotein
	Rabies virus Glycoprotein	Nicotinic Acetylcholine receptor	BBB & Neurons	(Gao et al., 2014; Kang et al., 2016; Kumar et al., 2007; Liu et al., 2016, 2013, 2009; Park et al., 2015)
Neurotoxin
	Tetanus Toxin C Fragment	Ganglioside receptor	Neurons	(Calvo et al., 2011; Moreno-Igoa et al., 2010)
Shape
	Rod-shaped			(Kolhar et al., 2013; Shyam et al., 2015)
	Star-shaped			(Joshi et al., 2018; Qian et al., 2014)