Figure 1.

Adult male mice were administered vehicle (water, VEH) or perfluorooctanesulfonate (PFOS, 100 µg/kg/day) and fed ad libitum (AL) or placed on a 25% kcal calorie restriction (CR) for approximately 6 weeks. (A) Percent change (%) in body weight from day 0 and (B) AUC of percent body weight illustrates that PFOS did not alter CR-induced percent weight loss at the time of necropsy. (C) Liver weight and (D) white adipose tissue (WAT) weights were decreased by CR. Liver weight was similar between AL-Veh and AL-PFOS groups, but liver weight was slightly increased in mice treated with PFOS (CR-PFOS) that underwent CR compared with vehicle controls (CR-VEH). Asterisks (*) represent a statistical difference in treatments compared with controls, and # represents a significant difference between CR-VEH versus CR-PFOS (p < .05).