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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Clin Cancer Res. 2020 Dec 3;27(5):1316–1328. doi: 10.1158/1078-0432.CCR-20-3208

Figure 4: Proposed algorithm for RET fusion detection.

Figure 4:

(A) Screening using DNA-based NGS and confirmation using RNA-based NGS. (B) Screening using break-apart FISH and confirmation using RNA-based NGS when DNA-based NGS is not available. DNA-based NGS is preferable to FISH as a screen due to higher sensitivity for NCOA4-RET fusions. While RET fusion testing is clinically indicated for advanced lung and thyroid cancers, testing for other solid tumors may be considered to support ongoing clinical trials exploring pan-cancer indications.