TABLE 3.
Associations between duration of paracetamol exposure during pregnancy and temperamental traits in preschool-aged children
| Temperamenta | Total n | Mean T score (SD) | Unadjusted β (95% CI) | Adjusted β (95% CI) |
|---|---|---|---|---|
| Emotionality | ||||
| Never user | 17 416 | 49.7 (10.0) | 0.00 (Reference) | 0.00 (Reference) |
| Paracetamol use in one trimester | 8228 | 50.1 (9.9) | 0.31 (0.05, 0.57) | 0.24 (−0.06, 0.53) |
| Paracetamol use in two trimesters | 4858 | 50.2 (9.9) | 0.46 (0.14, 0.77) | −0.01 (−0.44, 0.41) |
| Paracetamol use in three trimesters | 1756 | 50.6 (10.1) | 0.81 (0.31, 1.30) | 0.13 (−1.08, 1.33) |
| Activity | ||||
| Never user | 17 612 | 49.9 (10.0) | 0.00 (Reference) | 0.00 (Reference) |
| Paracetamol use in one trimester | 8303 | 49.9 (10.0) | 0.03 (−0.23, 0.29) | −0.08 (−0.38, 0.21) |
| Paracetamol use in two trimesters | 4901 | 49.9 (9.9) | −0.02 (−0.33, 0.29) | −0.04 (−0.48, 0.39) |
| Paracetamol use in three trimesters | 1771 | 50.1 (10.2) | 0.25 (−0.25, 0.75) | 0.51 (−0.57, 1.60) |
| Sociability | ||||
| Never user | 17 604 | 50.0 (9.9) | 0.00 (Reference) | 0.00 (Reference) |
| Paracetamol use in one trimester | 8298 | 50.0 (9.9) | 0.06 (−0.20, 0.32) | 0.02 (−0.27, 0.32) |
| Paracetamol use in two trimesters | 4908 | 50.2 (10.0) | 0.23 (−0.09, 0.54) | 0.30 (−0.12, 0.73) |
| Paracetamol use in three trimesters | 1777 | 50.1 (9.8) | 0.03 (−0.45, 0.51) | −0.07 (−1.02, 0.88) |
| Shyness | ||||
| Never user | 17 512 | 50.1 (10.0) | 0.00 (Reference) | 0.00 (Reference) |
| Paracetamol use in one trimester | 8252 | 50.0 (9.9) | −0.10 (−0.36, 0.16) | −0.17 (−0.46, 0.13) |
| Paracetamol use in two trimesters | 4874 | 49.8 (9.8) | −0.30 (−0.61, 0.01) | −0.62 (−1.05, −0.19) |
| Paracetamol use in three trimesters | 1760 | 50.0 (10.0) | −0.07 (−0.56, 0.42) | −0.24 (−1.27, 0.80) |
Note: Adjusted estimates are weighted with combined weights (IPTW × IPCW).
Abbreviations: SD, standard deviation; CI, confidence interval.
a
Temperamental traits were assessed by the EAS.