Table 2.
Laboratory and chest computed tomography findings.
| Total (n = 470) | Dyspnea (n = 447) | No dyspnea (n = 23) | P-value | |
|---|---|---|---|---|
| Blood gas analysis, median (IQR) | ||||
| pH | 7.44 (7.4–7.46) | 7.44 (7.4–7.46) | 7.44 (7.41–7.47) | 0.398 |
| PaCO2, mmHg | 31.2 (27.8–34.9) | 31.1 (27.8–34.7) | 33.4 (29.5–37.2) | 0.71 |
| HCO3-, mmol/L | 21.3 (18.9–23.7) | 21.2 (18.8–23.5) | 23.6 (20.6–25.8) | 0.008 |
| PaO2, mmHg | 63.5 (52.9–77.1) | 63.5 (53.1–77.1) | 66.4 (49–77.6) | 0.922 |
| FiO2, % | 60 (40–60) | 60 (40–60) | 60 (40–60) | 0.935 |
| PaO2/FiO2 ratio, mmHg | 124.67 (96.67–173) | 124.67 (96.67–172.75) | 129.33 (82–196.67) | 0.597 |
| Elevated A-a O2 gradienta, n (%) | 447 (95.1) | 426 (95.3) | 21 (91.3) | 0.386 |
| Blood workup, median (IQR) | ||||
| Glucose, mg/dL | 141 (113−211) | 144 (114–214) | 106 (96–140) | 0.002 |
| Creatinine, mg/dL | 1 (0.77–1.3) | 1 (0.77–1.3) | 1 (0.87–1.28) | 0.885 |
| Ureic nitrogen. mg/dL | 20.5 (14.3–30.2) | 20.55 (14.4–30.3) | 18.9 (12.225.9) | 0.28 |
| Serum lactate, U/L | 1.8 (1.4–2.5) | 1.8 (1.4–2.5) | 1.5 (1–2.1) | 0.027 |
| Lactic dehydrogenase, U/L | 465 (365–596) | 470 (365–598) | 429 (333–572) | 0.143 |
| Creatine kinase, U/L | 103.5 (56–211) | 103 (56–207) | 157 (60–350) | 0.364 |
| Ferritin, ng/dL | 696.4 (408.8–1203.4) | 708.25 (417.7–1222.4) | 627 (315.7–916) | 0.161 |
| D-dimer, ng/dL | 1092 (715–1997) | 1092 (715–2009) | 1100 (734–1834) | 0.775 |
| Fibrinogen, mg/dL | 757 (630–906) | 758 (630–913) | 693 (544–798.5) | 0.149 |
| C-reactive protein, mg/dL | 19.68 (14.07–28.23) | 19.8 (14.25–28.24) | 16.93 (6.5–25.68) | 0.099 |
| Hemoglobin, g/dL | 15 (13.8–16.2) | 15 (13.9–16.2) | 14.6 (13.3–15.7) | 0.118 |
| Neutrophils, 109/L | 8.63 (6.15–12.09) | 8.68 (6.2–12.2) | 7.52 (4.19–9.22) | 0.017 |
| Lymphocytes, 109/L | 0.69 (0.48–0.99) | 0.69 (0.46–1) | 0.77 (0.61–0.93) | 0.342 |
| Neutrophil/lymphocyte ratio | 11.79 (7.43–19.98) | 12.08 (7.57–20.46) | 8.26 (5.89–12.29) | 0.015 |
| Platelets, 109/L | 245 (198–330) | 245 (197–335) | 254 (201–286) | 0.797 |
| Chest CT severity, n (%) | 0.175 | |||
| Mild, <20% | 4 (0.9) | 3 (0.7) | 1(4.3) | |
| Moderate, 20%–50% | 62 (13.2) | 59 (13.3) | 3 (13) | |
| Severe, >50% | 402 (85.9) | 383 (86.1) | 19 (82.6) | |
Abbreviations: IQR, interquartile range; PaCO2, arterial partial pressure of carbon dioxide; HCO3-, bicarbonate; PaO2, arterial partial pressure of oxygen; FiO2, fraction of inspired oxygen; A-a O2, alveolar–arterial oxygen; CT, computed tomography.
a
Adjusted for barometric pressure and age.