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. 2021 Jul 12;13:5573–5585. doi: 10.2147/CMAR.S307595

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© 2021 Ni et al.

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CircHIPK3 silencing hampered tumor growth and promoted PTX sensitivity in vivo. (A) Representative images of the xenograft tumors at day 21 derived from sh-NC-infected or sh-circHIPK3-transduced MCF-7/PTX cells with NS (PBS) or PTX (3 mg/kg) administration. (B) Growth curves of the xenograft tumors formed by subcutaneous injection into the nude mice of sh-NC-infected or sh-circHIPK3-transduced MCF-7/PTX cells with NS (PBS) or PTX administration (n = 6 per group). (C) Tumor weight at day 21 of the xenograft tumors (n = 6 per group). Relative circHIPK3 (D), miR-1286 (E), HK2 mRNA (F) expression levels by qRT-PCR, HK2 protein level by Western blot (G) and immunohistochemistry (H) in the subcutaneous xenograft tumors (day 21, n = 6 per group). *P < 0.05, **P < 0.01 or ***P < 0.001 by ANOVA with Tukey’s post hoc test.