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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: J Diabetes Complications. 2020 Apr 28;34(9):107605. doi: 10.1016/j.jdiacomp.2020.107605

Figure.

Figure

Adjusted odds ratios were obtained from ordinal logistic regression modeling of intracranial atherosclerotic stenosis (ICAS) on glucose or HbA1c for participants without diagnosed diabetes (N=1139, Panels A and B), with diagnosed diabetes (n=509, Panels C and D) at Visit 5 using restricted cubic splines. Knots were placed at diabetes status-specific 10th, 25th, 50th, 75th, and 90th percentiles of glucose (5.0, 5.3, 5.7, 6.2, and 6.7 for non-diabetes; 5.2, 5.9, 6.8, 8.3, and 9.9 for diabetes, respectively [mmol/L]) or HbA1c (33, 36, 38, 41, and 43 mmol/mol [5.2, 5.4, 5.6, 5.9, and 6.1 %] for non-diabetes; (38, 41, 45, 53, and 64 mmol/mol [5.6, 5.9, 6.3, 7.0, and 8.0 %] for diabetes). Solid lines and dotted lines respectively show odds ratios and the corresponding 95% confidence intervals of being in higher categories of ICAS. The median value was set as reference (OR=1.0, depicted in a solid black line) within each group. The cubic lines were truncated at values of 1st and 99th percentile of glucose or HbA1c. Odds ratios were adjusted for age, sex, race-center (5 categories), education, medications for hypertension and cholesterol (yes/no), systolic blood pressure (mmHg), non-HDL-cholesterol (mg/dL), smoking (current/non-current) at Visit 5. The histogram represents the frequency distribution of glucose or HbA1c.