Table 2.
Odds ratios (OR) of intracranial atherosclerotic stenosis according to diagnosed diabetes-specific quantile of glucose and HbA1c measured at visit 5 (N=1,644)
| Diabetes status-specific quantiles | No. | Median | Range (min-max) | Unweighted model |
Weighted model |
||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95%CI | OR | 95%CI | ||||||
| Glucose (mmol/L) | |||||||||
| Non-diabetes, Q1 | 262 | 2.36 | (1.94- 2.46) | 1 (ref) | - | - | 1 (ref) | - | - |
| Non-diabetes, Q2-3 | 584 | 2.64 | (2.49- 2.85) | 1.28 | 0.92 | , 1.79 | 1.37 | 0.92 | , 2.06 |
| Non-diabetes, Q4 | 289 | 3.06 | (2.88- 5.85) | 1.28 | 0.88 | , 1.87 | 1.88 | 1.18 | , 3.00 |
| Diabetes, Q1 | 124 | 2.50 | (1.27- 2.72) | 1.13 | 0.69 | , 1.85 | 1.03 | 0.58 | , 1.83 |
| Diabetes, Q2-3 | 255 | 3.13 | (2.75- 3.86) | 1.21 | 0.81 | , 1.81 | 1.53 | 0.92 | , 2.52 |
| Diabetes, Q4 | 130 | 4.51 | (3.89- 9.27) | 1.71 | 1.08 | , 2.70 | 2.01 | 1.08 | , 3.72 |
| Overall p-value for trend | 0.04 | 0.02 | |||||||
| HbA1c (mmol/L in first rows, % in second rows) | |||||||||
| Non-diabetes, Q1 | 345 | 34 | (14- 36) | 1 (ref) | - | - | 1 (ref) | - | - |
| 5.3 | (3.4- 5.4) | ||||||||
| Non-diabetes, Q2-3 | 575 | 39 | (37- 41) | 1.16 | 0.86 | , 1.57 | 1.11 | 0.77 | , 1.59 |
| 5.7 | (5.5- 5.9) | ||||||||
| Non-diabetes, Q4 | 215 | 43 | (42- 61) | 1.21 | 0.83 | , 1.77 | 1.06 | 0.67 | , 1.69 |
| 6.1 | (6.0- 7.7) | ||||||||
| Diabetes, Q1 | 146 | 39 | (27- 41) | 1.04 | 0.67 | , 1.61 | 0.97 | 0.58 | , 1.63 |
| 5.7 | (4.6- 5.9) | ||||||||
| Diabetes, Q2-3 | 240 | 46 | (42- 53) | 1.10 | 0.75 | , 1.62 | 1.13 | 0.68 | , 1.88 |
| 6.4 | (6.0- 7.0) | ||||||||
| Diabetes, Q4 | 123 | 62 | (54- 116) | 1.72 | 1.10 | , 2.68 | 1.38 | 0.81 | , 2.33 |
| 7.8 | (7.1- 12.8) | ||||||||
| Overall p-value for trend | 0.03 | 0.24 | |||||||
Odds ratios were adjusted for age, sex, race-left (five categories), education, medications for hypertension and cholesterol (yes/no), systolic blood pressure (mmHg), non-HDL-cholesterol (mg/dL), and smoking (current/non-current). Those adjusting covariates were the ones assessed at Visit 5. Overall p-value for trend was obtained by modelling the category median (for all six categories) as a continuous variable. 95%CI, 95% confidence interval.