Table 3.

Criteria for Evaluation of Corneal Tissue for Transplantation Procedures²²

	Contraindications
Penetrating Keratoplasty (PK)	Infiltrates, pterygia, neovascularization, foreign bodies, stromal scars in graft area, detachment of Descemet‘s membrane, endothelial dystrophy, low endothelial cell density, Down syndrome, ectatic dystrophy (keratoconus, keratoglobus), previous refractive surgery (laser and incisional)
Anterior Lamellar Keratoplasty (ALK/DALK)	Infiltrates, pterygia, neovascularization, foreign bodies, stromal scars in graft area, Down syndrome, ectatic dystrophy, previous refractive surgery
Descemet’s stripping endothelial keratoplasty (DSEK/DSAEK)	Infiltrates, scars impacting posterior stroma in graft area, detachment of Descemet’s membrane, low endothelial cell density, low rim size and corneoscleral disc size (necessary for mounting on anterior chamber)
Descemet’s membrane endothelial keratoplasty (DMEK)	Infiltrates, foreign bodies, tears in Descemet’s membrane in graft area, low endothelial cell density
Keratolimbal Allograft (KLA)	Infiltrates, small scleral rim, conjunctiva not intact over the rim, melanoma, cancer of solid organ
Keratoprosthesis (K-Pro)	Infiltrates, pterygia, neovascularization, foreign bodies, significant thinning of the cornea, prior refractive surgery, Down syndrome, ectatic dystrophy

Note: Data from Eye Bank Association of America (EBAA).²²