Table 1.
Changing diagnostic work-up for celiac disease in children in the Netherlands
| Diagnostic tests No. (%) |
National surveys | 2010–2013 | |||||
|---|---|---|---|---|---|---|---|
| 1975–1990 Retrospective |
1993–2000 Prospective |
2010–2013 Prospective |
2010–2011 | 2012***–2013 | |||
| n=223 | n=1017 | n = 898 | n = 487 | n = 411 | |||
| Sympt. n=454 | Asympt. n=33 | Sympt. n=384 | Asympt. n=27 | ||||
| IgA AGA | 131 (59) | 915 (90) | 84 (9.4)* | 45 (9.9) | 0 | 39 (10.2) n.s. | 0 n.s. |
| 45 (9.2) | 39 (9.5) n.s. | ||||||
| IgA tTG | N.A.** | N.A.** | 869 (96.8) | 440 (96.9) | 33 (100) | 370 (96.4) n.s. | 26 (96.3) n.s. |
| 473 (97.1) | 396 (96.4) n.s. | ||||||
| IgA EMA | Unknown | 793 (78) | 543 (60.5)* | 223 (49.1) | 14 (42.4) | 288 (75.0)^ | 18 (66.7)^ |
| 237 (48.7) | 306 (74.5)* | ||||||
| HLA typing | Unknown | Unknown | 469 (52.2) | 107 (23.6) | 9 (27.3) | 329 (85.7)^ | 24 (88.9)^ |
| 116 (23.8) | 353 (85.9)^ | ||||||
| Biopsies | 223 (100) | 1017 (100) | 601 (66.9)* | 399 (87.9) | 30 (90.1) | 150 (39.1)^ | 22 (81.5)n.s. |
| 429 (88.1) | 172 (41.8)^ | ||||||
On the left side, the data from the three national surveys are presented (1975–2013), and on the right side, the data before and after the introduction of the non-biopsy approach
*p<0.01; NA not available at the time
**Widespread introduction throughout the Netherlands in 1999
***Publication of ESPGHAN Guideline. Comparison of data between 2010 and 2011 and 2012 and 2013: n.s., not significantly different or ^ significantly different