Table 1.
Baseline characteristics according to the presence/absence of overt thyroid dysfunction
| Characteristics | Overt Thyroid dysfunction | Non-overt thyroid dysfunction | p value |
|---|---|---|---|
| n = 11 | n = 57 | ||
| Age (years) | |||
| Median | 51 | 60 | 0.13 |
| Range | 29–72 | 27–82 | |
| Sex | |||
| Females | 7 (63.6%) | 19 (33.3%) | 0.08 |
| Male | 4 (36.4%) | 38 (66.6%) | |
| Tumor type | |||
| Melanoma | 8 (72.7%) | 31 (54.4%) | 0.39 |
| Lung | 1 (9.1%) | 6 (10.5%) | |
| Mesothelioma | 0 (0%) | 6 (10.5%) | |
| Others | 2 (18.2%) | 14 (24.6%) | |
| ICIs | |||
| PD1 | 9 (81.8%) | 36 (63.1%) | 0.44 |
| PD1 + CTLA4 | 2 (18.2%) | 14 (24.6%) | |
| PDL1 | 0 (0%) | 7 (12.3%) | |
| Pre-existing TPOAbs1 | |||
| Positive | 3 (30%) | 1 (1.9%) | 0.01 |
| Negative | 7 (70%) | 52 (98.2%) | |
| TSH at baseline (mUI/L) | |||
| Median | 2.6 | 1.6 | 0.003 |
| Range | 1.7–3.9 | 0.40–3.9 | |
| FT4 at baseline (pg/ml) | |||
| Median | 8.2 | 9.7 | 0.07 |
| Range | 6–11 | 6.1–13.7 | |
| Thyroid volume at baseline (ml) | |||
| Median | 12 | 14 | 0.25 |
| Range | 7.9–11 | 6–45.7 | |
| Thyroid hypoechogenicity2 | |||
| Yes | 3 (27.2%) | 5 (11.4%) | 0.17 |
| No | 8 (72.8%) | 39 (88.6%) | |
| Follow-up median (days) | 133 | 164 | 0.43 |
1Baseline TPOAbs available in 63 patients
2Thyroid ultrasound performed at baseline in 55 patients
Significant p values are in bold