Table 1.
Physiochemical properties of SRI-37240 and SRI-41315.
| Assay | Target values | SRI-37240 | SRI-41315 |
|---|---|---|---|
| MW (g/mol) | <500 | 387.5 | 357.4 |
| HLM t1/2 (min) | >60 | 82 | 300 |
| MLM t1/2 (min) | >30 | 10 | 205 |
| Solubility (μM) | >10 | <1 | 51 |
| Log D | 2–4 | 4.5 | 2.4 |
| Polar surface area | 40–90 | 53 | 53 |
| Cell permeability | 10 × 10−6 cm/s, ER<2 | 7.3 × 10−6, ER = 6 | 22.99 × 10−6, ER = 1.08 |
| CC50, FRT cells | >50 μM | >50 μM | >50 μM |
| CC50, 16HBE cells | >50 μM | >50 μM | >50 μM |
CC50 values (50% cytotoxic concentration) are defined as the compound’s concentration (µg/mL) required for the reduction of cell viability by 50%.