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. 2021 Jul 16;11:14611. doi: 10.1038/s41598-021-93998-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Correlation between CTSA and FTL (r = 0.4042), GRN (r = 0.4132), HEXB (0.4641), NPC2, (r = 0.4646), PTGES2 (r = 0.3533), all P < 0.05. (B) The Kaplan–Meier curve showed that the mRNA expression of FTL, GRN, NPC2, and HEXB were significantly related to the OS in HCC patients (all P < 0.05). (C) The main enriched KEGG pathways of CTSA. OXIDATIVE PHOSPHORYLATION, LYSOSOME, OTHER GLYCAN DEGRADATION, PENTOSE PHOSPHATE PATHWAY, PROTEASOME, AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM, GLUTATHIONE METABOLISM, FRUCTOSE AND MANNOSE METABOLISM, ALZHEIMERS DISEASE, GLYCEROPHOSPHOLIPID METABOLISM.