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. 2021 Jul 16;5:67. doi: 10.1038/s41698-021-00203-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — CNAs in predominant pathways are annotated (gain in red, loss in blue). a CNA profiles of CTCs, corresponding leucocytes, and germline DNA from patient P46 resistant to crizotinib. b CNA profile of CTC, corresponding leucocytes, and germline DNA from patient P41 resistant to lorlatinib. c Ploidy determined for each CTC sample. P43 samples contain pools of 5 (CTC 1) or 10 (CTC 2, CTC 3) CTCs. CTC 1 of P46 is a pool of 2 CTCs. All other samples are single CTCs.