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. 2021 Jul 16;5:67. doi: 10.1038/s41698-021-00203-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The altered genes are attributed to pathways. The pathways are sorted from the most to the least altered. The number of altered genes per pathway is shown in parentheses. CNA drivers present in patients at resistance to crizotinib only, in patients at resistance to lorlatinib only, and in both, are annotated “C”, “L” and “C/L” respectively in the “Groups” column. CNA driver function (activating or loss of function) is mentioned in the “Role” column. Frequencies of gain and loss in the 39 samples (38 CTC samples and 1 biopsy) are provided. Red and blue colors represent gains and loss respectively.