Fig. 4. Sensitivity plots comparing the effect of covariates on steady-state exposure.
a Cmin; b Cmax; c Caverage. Vertical reference lines represent the typical steady-state exposure value of a 62-kg patient with an albumin level of 44 g/L receiving 200 mg of camrelizumab every 2 weeks. The top bars in each plot represent the 5%–95% exposure values across the entire population. The labels at each of the lower bars indicate the range of the covariate values. The length of each bar describes the impact of that particular covariate on the observed PK parameter