Table 3.
Population pharmacokinetic parameter estimates and bootstrap evaluation.
| Parameters | Base model | Final model | |||
|---|---|---|---|---|---|
| Parameter estimates (%CV) |
Shrinkage (%) |
Parameter estimates (%CV) |
Shrinkage (%) |
Bootstrap Median (2.5%–97.5%) |
|
| CLlinear (L/day) | 0.242 (2.7) | / | 0.231 (6.1) | / | 0.23 (0.20–0.26) |
| Albumin on CLlinear | / | / | −1.98 (24.2) | / | −1.93 (−2.94 to −0.89) |
| Vm (mg/day) | 2.86 (3) | / | 2.94 (7.5) | / | 3.00 (2.26–3.71) |
| Km (mg/L) | 1.28 (1.4) | / | 1.38 (13) | / | 1.40 (0.91–2.76) |
| V1 (L) | 3.08 (2.7) | / | 3.07 (3.7) | / | 3.08 (2.77–3.33) |
| Q (L/day) | 0.385 (3.8) | / | 0.414 (6.7) | / | 0.41 (0.34–0.51) |
| weight on Q | / | / | 1.22 (26.9) | / | 1.18 (0.31–2.28) |
| V2 (L) | 2.88 (2.8) | / | 2.9 (3.6) | / | 2.91 (2.35–3.35) |
| Between-subject variability | |||||
| CLlinear (%) | 57.0 (17.3) | 11.6 | 50.8 (17.9) | 13 | 50.2 (32.7–68.9) |
| Vm (%) | 48.3 (17.5) | 17.5 | 49.5 (17.6) | 18 | 47.8 (29.4–70.9) |
| V1 (%) | 40.2 (13.3) | 3 | 40.7 (13.6) | 3 | 39.0 (17.0–70.68) |
| Residual variability | |||||
| Proportional error (%) | 29.4 (1.7) | 4.5 | 29.3 (3) | 4.5 | 28.9 (23.8–33.9) |
| Additive error (mg/L) | 0.0812 (3.2) | 4.5 | 0.0827 (31.7) | 4.5 | 0.0823 (0.0293–0.112) |
CLlinear clearance of linear elimination, Vm maximum elimination rate, Km Michaelis–Menten constant, V1 distribution volume of central compartment, Q intercompartmental clearance, V2 distribution volume of peripheral compartment.