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. 2021 Apr 15;42(8):1223–1234. doi: 10.1038/s41401-021-00664-x

Fig. 4. The effect of pinocembrin on BBB structure and permeability.

Fig. 4

Delayed t-PA treatment significantly increased EB leakage, brain water content, and BBB disruption. Pinocembrin dramatically reversed these effects. a Representative images of EB leakage. b EB content. c Representative images of BBB structure. d Brain water content. The data are presented as the mean ± SEM. ##P < 0.01 and ###P < 0.001 compared with the sham group; *P < 0.05 and **P < 0.01 compared with the t-PA group; n = 5; bar = 500 nm.