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. 2021 Apr 15;42(8):1223–1234. doi: 10.1038/s41401-021-00664-x

Fig. 9. The effect of pinocembrin on the production and transport of lactic acid in the cerebral cortex and serum.

Fig. 9

Delayed t-PA treatment induced the release of lactic acid. Pinocembrin markedly decreased the content of lactic acid. a The content of lactic acid in the cerebral cortex. b The content of lactic acid in the serum. c The activity of LDH in the cerebral cortex. d The activity of LDH in the serum. e Representative images of MCT 1 expression in the cerebral cortex. f The change in MCT 1 expression. The data are presented as the mean ± SEM. ##P < 0.01 and ###P < 0.001 compared with the sham group; $P < 0.05 and $$P < 0.01 compared with the vehicle group; *P < 0.05 and **P < 0.01 compared with the t-PA group; n = 5.