Table 3.

Regression analysis of factors associated with severe leptospirosis.

Parameters	Odds ratio (95% CI) unadjusted	p-value	Odds ratio (95% CI) Adjusteda	p-value
Gender	1.02 (0.48–2.16)	0.967	1.00 (0.99–1.02)	0.807
Age	1.00 (0.99–1.02)	0.731	0.96 (0.44–2.11)	0.925
Days of fever until enrollment	1.05 (0.92–1.21)	0.456	1.05 (0.92–1.21)	0.465
Leptospiremia (log10 copies/ml)	1.66 (1.21–2.27)	0.002*	1.70 (1.23–2.34)	0.001*
MAT titer (log scale)	0.49 (0.03–8.11)	0.617	0.35 (0.01–8.79)	0.523
Plasma NGAL (log10 ng/ml)	8.51 (3.88–18.67)	< 0.001*	9.46 (4.20–21.33)	< 0.001*
IL-6 (log10 pg/ml)	2.61 (1.84–3.70)	< 0.001*	2.82 (1.96–4.07)	< 0.001*

pNGAL plasma neutrophil gelatinase-associated lipocalin, IL-6 interleukin 6, MAT microscopic agglutination test.

*p-value < 0.05.

^aAdjusted for gender, age, and days of fever until enrollment.