Fig. 6. Systemic control of bacterial load and survival after intravenous F. tularensis infection are enhanced in the presence of MAIT cells.

A–E WT (C57BL/6) or Mr1^−/− mice were infected i.v. with 2 × 10⁴ CFU F. tularensis LVS. The bacterial burden (CFU) in the liver, lung, spleen, kidney, and blood (100 μl) was assessed at the indicated dpi. 0 dpi was examined at 4 h after inoculation. Pooled data (mean ± SEM) from two independent experiments with similar results. Two-way ANOVA on log-transformed data. P-values < 0.05 are indicated. Numbers in brackets indicate number of mice: n = (WT, Mr1^−/−). F Survival of WT (C57BL/6) or Mr1^−/− mice (n = 18 mice per group) challenged with 2.5 × 10⁴ CFU F. tularensis LVS. Log-rank test. P-value is indicated. Source data are provided as a Source Data file.