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. 2020 Nov 5;42(8):1212–1222. doi: 10.1038/s41401-020-00553-9

Table 1.

The main features of three commonly used Tu-San-Qi-related herbs.

Items Comparison of three kinds of 三七 San-Qi
Chinese name 三七 景天三七 菊三七
(Prescribed, nontoxic) (Self-medication, nontoxic) (Self-medication, toxic)
Chinese Pinyin name San-Qi Jing-Tian-San-Qi Ju-San-Qi
Synonym Tian-Qi, Dian-San-Qi, Jin-Bu-Huan Tu-San-Qi, Fei-Cai, Ba-Xian-Cao Tu-San-Qi, Jian-Zhong-Xiao, Ru-Xiang-Cao, Nai-Cao
Origin Roots of Panax notoginseng (Burkill) F.H. Chen Roots or whole herbs of Sedum aizoon L. Roots or whole herbs of Gynura japonica (Thunb.) Juel
Plant morphologies Herbs, perennial, 20–60 cm tall Herbs, perennial, fleshy, hairless, 20–80 cm tall Herbs, perennial, high and robust, 60–100 cm or taller
Growing environment Forests; ASL 1200–1800 m Scrub, ravine edges in valleys, grasslands on rocky slopes, and so on; ASL1000–3100 m Valleys, grassy slopes, forests, forest margins; ASL 1200–3000 m
Distribution in China and the world SE Yunnan; cultivated in Fujian, SW Guangxi, Jiangxi, Zhejiang [N Vietnam] Anhui, Gansu, Hebei, Heilongjiang, Henan, Hubei, Jiangsu, Jiangxi, Jilin, Liaoning, Nei Mongol, Ningxia, Qinghai, Shaanxi, Shandong, Shanxi, Sichuan, Zhejiang [Korea, Japan, Mongolia, Russia] Anhui, Fujian, Guangxi, Guizhou, Hebei, Henan, Hubei, Hunan, Jiangsu, Jiangxi, Shaanxi, Sichuan, Taiwan, Yunnan, Zhejiang [Japan, Nepal, Thailand]
Macroscopic features of the medicinal part

The roots are conical, spindle-shaped, or irregularly shaped, 1–6 cm long and 1–4 cm in diameter. The surface is grayish yellow to brownish black, with waxy luster, stem marks on the top, knob-like protrusions around, intermittent longitudinal wrinkles on the sides, and root fractures. The weight and texture are solid. After breaking, the section is grayish green, yellowish green, or grayish white;

It smells a bit scent, tastes sweet after bitter

The rhizome is short and slightly blocky; the surface is grayish brown, with several roots and varying thickness; the texture is hard and the section is dark brown or white;

It smells a bit scent, tastes harsh

The root is a fist-shaped round block with a length of 3–6 cm and a diameter of about 3 cm. The surface is grayish brown or brownish yellow. There are many tumor-like protrusions on the whole. There are often stems or buds on the top of the protrusions. Broken. It is solid, not easy to break, the section is not flat, it is white when fresh, and the dry is yellowish;

It has no smell, tastes slightly bitter

Function and indication in folk medicine

1. Stop bleeding and dissipate blood stasis

2. eliminate swelling and relieve pain. Treat various hemorrhagic diseases

1. dissipate blood stasis and stop bleeding, detoxify. Mainly treat vomiting blood, hemoptysis, defecation hemorrhage, traumatic bleeding, dysmenorrhea, traumatic injury, insect bite and so on

1. Stop bleeding and dissipate blood stasis

2. Eliminate swelling and relieve pain

3. Dissipate heat and detoxify. Mainly treat vomiting blood, hemoptysis, defecation hemorrhage, traumatic bleeding, dysmenorrhea, traumatic injury, insect bite, etc.

Bioactive constituents Ginsenosides, amino acids, volatile oil Monosaccharide, disaccharide, flavonoids

Pyrrolizidine alkaloids,

3-epi-diosgenin-3-β-D-glucopyranoside

Usage and dosage

Oral: 3–9 g (decoction), 1–3 g (powder)

External: moderate amount

Oral: 15–30 g (decoction), 30–60 g (Fresh herbs in squeezing juice)

External: moderate amount

Oral: 3–15 g (roots in decoction), 1.5–3 g (roots in powder), 10–30 g (whole herbs or leaves)

External: moderate amount

Earliest literature

Compendium of Materia Medica

(本草纲目)

A.D. 1596

Jiuhuang Materia Medica

(救荒本草)

A.D. 1406

Diannan Materia Medica

(滇南本草)

A.D. 1436