Fig. 5. Effect of JNK pathway blockade on H₂O₂-mediated changes in ASIC currents.

a Representative whole-cell recordings of ASIC currents in the presence or absence of H₂O₂ (20 μM) for 24 h in NS20Y cells and in the presence or absence of JNK inhibitor SP600125 (SP, 10 μM). b Summary of the data showing the alteration of ASIC current density by H₂O₂ in the presence or absence of SP600125 (n = 20–23 cells, P = 0.04 and P = 0.004 versus vehicle control, P < 0.001 versus H₂O₂ alone, one-way ANOVA). SP600125 or vehicle (0.1% DMSO) was added 1 h prior to and during H₂O₂  treatment.