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. 2021 Jul 16;7:93. doi: 10.1038/s41523-021-00303-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Significant MBC driver mutations across metastatic sites are shown by comparing 27 candidate driver mutations from MBC of a specific metastatic site with other metastatic sites or PBC. Presented results are from the logistic regression analysis for mutational frequency of 27 candidate driver mutations between MBC samples from different metastatic sites. Truncating mutations are represented by “Trunc” and missense mutations are shown by their amino acid change. Odds ratios and 95% CI for each mutation were shown and asterisks indicate statistical significance at FDR < 0.01. b MBC driver genes of WTSI and INSERM cohort data which had sufficient background mutations from the results of MutSigCV and dNdScv. c Mutation types of ESR1 shown in a lollipop plot. Red-colored variants are candidate driver mutations enriched in MBC samples. X-axis indicates amino acid position.