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. 2021 Jul 16;11:14579. doi: 10.1038/s41598-021-93780-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Lesional skin from psoriasis patients expresses low levels of GADD45a and GADD45b. (A) mRNA levels of GADD45a (left) and GADD45b (right) were analyzed by qRT-PCR in skin samples from 30 patients with psoriasis and 15 controls. GAPDH was used to normalize gene expression. Data were analyzed by one-way ANOVA followed by Tukey’s multiple comparisons test. (B) Representative staining of GADD45a (green) and CD3 (red) in skin samples from lesional skin and non-lesional skin. Quantification of immunofluorescence staining, fluorescence intensity of GADD45 in epidermal (left) and dermal (right) infiltrating T cells was calculated using the Image J software. Differences between groups were determined by one-way ANOVA followed by Tukey’s multiple comparisons test. (C) Correlation analysis of GADD45a and GADD45b mRNA expression in lesional skin of psoriasis patients and disease severity evaluated (PASI score).