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. 2021 Jul 16;11:14579. doi: 10.1038/s41598-021-93780-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The promoter region of UCHL1 in lesional skin of psoriasis patients show a higher index of methylation. (A) Methylation ratio of the promoter region of UCHL1 in lesional skin samples from psoriasis patients (n = 6) and healthy skin from control subjects (n = 5). Methylated status of UCHL1 promoter was analyzed using methylation specific PCR. Data were analyzed using Mann Whitney U test. (B) Expression of UCHL1 in skin samples from psoriasis patients (lesional and non-lesional) and control subjects. UCHL1 expression was analyzed using qRT-PCR and data were normalized to GADPH. Data were analyzed using One-way ANOVA and Tukey’s multiple comparisons test. (C) Scatter graphs showing the positive correlation between the levels of GADD45a and UCHL1 in lesional skin of psoriasis patients. Data were analyzed using Spearman test.