Table 2.
Differentially methylated CpG sites in UCHL1 promotor in skin samples from psoriasis patients. Location: genomic coordinate_37 of the CpG site interrogated by the probe. CpG-site neighborhood: location of the gene-associated CpG-site(s) within the CpG-site neighborhood.
| Dataset | Reference | DMS | Location | CpG-site neighborhood | Adj p value | Gene context | log2 FC | Methylation state |
|---|---|---|---|---|---|---|---|---|
| GSE63315 (L vs HC) | 1 | cg16026922 | 41,259,044 | Island | 1,38E-03 | Body | 5,68E−02 | Hypermethylated |
| cg16142306 | 41,258,935 | Island | 1,94E-03 | 1stExon;5'UTR | 3,70E−02 | Hypermethylated | ||
| GSE73894 L vs HC | 2 | cg24715245 | 41,258,794 | Island | 1,49E-03 | TSS200 | − 3,22E−02 | Hypomethylated |
| cg09921610 | 41,259,866 | Island | 6,56E-03 | Body | 2,95E−02 | Hypermethylated | ||
| GSE73894 L vs NL | cg09921610 | 41,259,866 | Island | 6,06E-03 | Body | − 3,50E−02 | Hypomethylated | |
| GSE115797 | 3 | cg07068756 | 41,258,910 | Island | 1,05E-02 | 1stExon;5'UTR | 7,52E−02 | Hypermethylated |
Gene context: location of the gene-associated CpG-site(s) with respect to the gene context. Abbreviations: Adj p value: adjusted p value; CpG: Cytosine-Phosphate-Guanine sites; DMS: differentially methylated sites; HC: Healthy control skin; Log2FC: logarithm of the fold change of methylation values in psoriasis samples with respect to controls; L: psoriasis lesional skin; NL: psoriasis non-lesional skin; TSS200 Promoter regions 200 bp (base pairs) upstream of the transcription start site; 5’-UTR: 5’-untranslated region; vs: versus.