Fig. 2. Nomination of cancer genes in cutaneous squamous cell carcinoma.

a A Venn diagram depicting nominated cancer genes from four separate cancer gene discovery programs, each designed to identify genes under positive selection in cancer. The set of candidate genes were further curated, as described, to nominate candidates for which additional evidence is warranted (red text) or not (blue text). b A list of mutations in our study that overlap mutations in the cancerhotspots.org database. Mutations are grouped by gene and ordered by their q values (lowest to highest). These mutations were also curated, as described, to nominate candidates for which additional evidence is warranted (Possible False Positive) or not (Likely Driver).