Fig. 4. The landscape of driver mutations in cutaneous squamous cell carcinoma.

a Tiling plot of the genetic alterations (rows) in each tumor (columns). Genes and tumors are further organized into pathways and clinical subtypes. The percentages of samples harboring pathogenic alterations are indicated. Mut mutation, Amp amplification, XPC xeroderma pigmentosum, RDEB recessive dystrophic epidermolysis bullosa. b Pathways affected. TERT was not implicated in this study, which focused on coding mutations, but is included here because it is known to have promoter mutations, as described.