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. 2021 Jul 16;12:4357. doi: 10.1038/s41467-021-24574-y

Fig. 8. VUN103 and Nb7 recognize different US28 conformations.

Fig. 8

Apo-US28 constitutively binds Gαq proteins resulting in constitutive signaling. VUN103 recognizes the US28 apo conformation and displaces Gαq proteins resulting in inhibition of US28 signaling. CX3CL1 binding to US28 results in a conformational change (Δ conformation) resulting in superactivation of US28 receptor. The ligand-bound US28-conformation is recognized by Nb7, resulting in competition with Gαq proteins, and subsequent inhibition of US28 signaling.