Table 3.
Characteristics of the Children with HAI According to Pattern of Carbapenem Resistance (CRKP or CSKP Isolates)
| Variable | CRKP (N=112) | CSKP (N=146) | P value |
|---|---|---|---|
| Age (months) | 0.53 (0.12–3.2) | 0.65 (0.17–12) | 0.27 |
| Male | 62 (55.4) | 82 (56.2) | 0.9 |
| Rural area | 74 (66.1) | 72 (49.3) | <0.01 |
| Underlying disease | |||
| Hematologic malignancies | 18 (16.1) | 26 (17.8) | 0.71 |
| Congenital anomalies | 19 (17) | 16 (11) | 0.16 |
| Prematurity | 58 (51.8) | 61 (41.8) | 0.11 |
| NEC | 9 (8) | 15 (10.3) | 0.54 |
| Solid tumors | 2 (1.8) | 1 (0.7) | 0.58 |
| Severe malnutrition | 7 (6.3) | 4 (2.7) | 0.28 |
| Departments | |||
| ● Hematology-oncology ward | 17 (15.2) | 25 (17.1) | 0.68 |
| ● General medical ward | 56 (50) | 58 (39.7) | 0.1 |
| ● NICU | 13 (11.6) | 44 (30.1) | <0.01 |
| ● PICU | 8 (7.1) | 7 (4.8) | 0.42 |
| ● Surgical ward | 18 (16.1) | 12 (8.2) | 0.051 |
| Length of hospitalization | 38.5 (24–56.3) | 30 (19.3–51.8) | 0 |
| Length of hospitalization before the onset of KP infections | 12.5 (2–24.3) | 10 (2–22) | 0.02 |
| Invasive procedures and devices | |||
| PICC | 37 (33) | 43 (29.5) | 0.54 |
| Thoracic cavity drainage | 6 (5.4) | 6 (4.1) | 0.64 |
| Abdominal indwelling catheter | 3 (2.7) | 1 (0.7) | 0.32 |
| Indwelling urinary catheter | 1 (0.9) | 4 (2.7) | 0.39 |
| Invasive mechanical ventilation | 51 (45.5) | 39 (26.7) | <0.01 |
| Surgical operation | 23 (20.5) | 32 (21.9) | 0.79 |
| Organ dysfunction (any) | 41 (36.6) | 22 (15.1) | <0.01 |
| Septic shock | 13 (11.6) | 13 (8.9) | 0.48 |
| Mortality or hopeless discharge | 16 (14.3) | 19 (13) | 0.77 |
| Combined organ infection | |||
| Pneumonia | 54 (48.2) | 60 (41.1) | 0.25 |
| Meningitis | 34 (30.4) | 21 (14.4) | <0.01 |
| Intrabdominal infections | 15 (13.4) | 23 (15.8) | 0.6 |
| Upper urinary tract infections | 2 (1.8) | 1 (0.7) | 0.58 |
Abbreviations: CRKP, carbapenem‐resistant Klebsiella pneumoniae; CSKP, carbapenem-sensitive Klebsiella pneumoniae; KP, Klebsiella pneumoniae; PICC, peripherally inserted central catheter; NEC, necrotizing enterocolitis; NICU, neonatal intensive care unit; PICU, pediatric intensive care unit.