Table 3.
Assessment of cardiac status in male vs. female Wistar and T2DN rats (>48 wk of age)
| Wistar >48 wk Group |
T2DN >48 wk Group |
|||||||
|---|---|---|---|---|---|---|---|---|
| Male |
Female |
Male |
Female |
|||||
| Means | ± SE | Means | ± SE | Means | ± SE | Means | ± SE | |
| HWT/TBW | 2.4 | 0.1 | 3.5* | 0.1 | 3.5 | 0.1 | 4.2* | 0.1 |
| Heart Fibrosis, % area | 5.6 | 2.5 | 4.7 | 0.6 | 4.0 | 1.6 | 7.1 | 2.2 |
| VWTs, mm | 3.2 | 0.3 | 2.7 | 0.2 | 2.9 | 0.1 | 2.7 | 0.1 |
| HR, beats/min | 338 | 11 | 359 | 14 | 295 | 17 | 349* | 14 |
| CO (Teich) L/min | 0.43 | 0.05 | 0.32 | 0.04 | 0.34 | 0.03 | 0.27 | 0.02 |
| EF(Cube), % | 80.3 | 2.5 | 81.9 | 2.8 | 72.5 | 3.0 | 73.5 | 2.3 |
| Fractional shortening, % | 42.3 | 2.6 | 44.1 | 2.8 | 35.6 | 2.4 | 36.2 | 1.8 |
n ≥ 3 for all groups.*P < 0.05 between male and female groups. CO, cardiac output; EF, ejection fraction; HW/TBW, heart weights normalized to total body weight; HR, heart rate; T2DN, Type 2 Diabetic Nephropathy. VWTs, echocardiogram analysis of left ventricle wall thickness in systole.