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The ErbB4-specific ligand NRG4 is expressed by proinflammatory macrophages. Wild-type BM-Mɸs were activated with IFN-ɣ/LPS; RNA and epithelial isolates were collected at 6 h and 24 h poststimulation. Nrg4 expression was determined by qPCR (A) and ELISA (B) in BM-Mɸs (n = cultures from 9 or 15 mice/group) and epithelial isolates (n = 5 mice). *P < 0.05; ***P < 0.001.
