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. 2021 Apr 26;320(6):E1107–E1118. doi: 10.1152/ajpendo.00281.2020

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Figure 8. — Model diagram of the effects of acute virilizing testosterone on the insulin pathway in tissues responsible for systemic insulin sensitivity. Components in red are upregulated. Components in green are downregulated. Solid arrows are significantly different. Dashed arrows reflect a trend in significance. AR, androgen receptor; ESR1, estrogen receptor α; FOXO1, forkhead box ortholog 1; INSR, insulin receptor; IRS1, insulin receptor substrate 1; mRNA: messenger RNA; pAKT^Ser473, phosphorylated(Ser473) AKT; pFOXO1^Ser256, phosphorylated(Ser256) FOXO1; PI3K, phosphoinositide 3 kinase; PI3K 110 α, phosphoinositide 3 kinase 110 α subunit; PPARG, peroxisome proliferator activated receptor gamma; scWAT, subcutaneous white adipose tissue; TAKT, total AKT; T FOXO1, total FOXO1; VWAT, visceral white adipose tissue.