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. 2021 Apr 22;130(6):1893–1902. doi: 10.1152/japplphysiol.00065.2021

Figure 1.

Figure 1.

Female muscle-specific knockout of sirtuin 1 (mKO) mice show no impairments in contractile function or fatiguability compared with wild type (WT). A and B: in WT and mKO mice, temporal force production recording during a 10-min contraction protocol (40 subsequent contractions) in the extensor digitorum longus (EDL; A) and soleus (B). In both EDL and soleus, there was a main effect of time (i.e., contraction) on force production, but no effect of genotype. P < 0.05. Statistics: data were analyzed by repeated measures two-way ANOVA. C and D: fatigue index (time taken for force to decrease to 60% and 40% of initial force) in the EDL (C) and soleus (D) of WT and mKO female mice. Statistics: data were analyzed by a repeated measures two-way ANOVA. Note: 2-deoxyglucose uptake was not measured in all muscles. Female: WT-soleus, n = 6; WT-EDL, n = 7; mKO-soleus, n = 7; mKO-EDL, n = 7. Data are presented as means ± SE.