Figure 4.

Contraction-stimulated glucose uptake is comparable in muscle-specific knockout of sirtuin 1 (mKO) and wild type (WT) of female mice. A and B: in WT and mKO female mice, 2-deoxyglucose uptake (2DOGU) in paired rested (Rest) and contracted (Contract.) extensor digitorum longus (EDL; A) and soleus (B). There was a main effect of contraction on 2DOGU but no effect of genotype. Statistics: data were analyzed by a repeated measures two-way ANOVA. *P < 0.05, main effect of contraction. C and D: contraction-stimulated (C-Stim) 2DOGU (i.e., Contraction 2DOGU – Rest 2DOGU) in the EDL (C) and soleus (D) from WT and mKO female mice. Statistics: data were analyzed by an unpaired t test. Female: WT-soleus, n = 6; WT-EDL, n = 7; mKO-soleus, n = 6; mKO-EDL, n = 7. Data are presented as means ± SE.