Figure 7.

Contraction-stimulated glucose uptake is higher in female vs. male mice. A and B: in female and male mice, rested (Rest) and contraction (Contract.) 2-deoxyglucose uptake (2DOGU) in paired extensor digitorum longus (EDL; A) and paired soleus (B); because there were no genotype differences in contraction-stimulated (C-Stim) 2DOGU, wild-type (WT), and muscle-specific knockout of sirtuin 1 (mKO) data were collapsed together to assess sex differences. Statistics: data were analyzed by a repeated measures two-way ANOVA. C and D: C-Stim 2DOGU in the EDL (C) and soleus (D) from male and female mice. Statistics: data were analyzed by an unpaired t test. E and F: in female and male mice, accumulated tension during the 10-min contraction protocol (summation of temporal force production recordings produced during 40 subsequent contractions) in the EDL (E) and soleus (F). Statistics: data were analyzed by an unpaired t test. G and H: fatigue index (time taken for force to decrease to 60% and 40% initial force) in the EDL (G) and soleus (H) female and male mice. Statistics: data were analyzed by a repeated measures two-way ANOVA. *P < 0.05, main effect of sex. Male: soleus, n = 14; EDL, n = 15. Female: soleus, n = 10-12; EDL, n = 13-14. Data are presented as means ± SE.