Change in outcome measures as a result of varying each of four key global parameters by ±2SD with respect to baseline. Total blood volume (Vtot), mean = 5625.0 mL, SD = 203.0 Ml (A); arterial baroreflex set point (Paspa), mean = 91.0 mmHg, SD = 3.0 mmHg (B); cardiopulmonary reflex set point (Paspc), mean = 8.0 mmHg, SD = 1.0 mmHg (C); and nominal heart rate (HRnom), mean = 70.0 beats/min, SD = 3.3 beats/min (D). Graphs showing the same outcome measure have the same y-axis scale.