Figure 2.

Disruption of the liver clock increases expression of select energy metabolism genes in PVAT. RT-PCR was used to assess the mRNA expression levels of peroxisome proliferator-activated receptor γ coactivator 1-α (Ppargc1a; A), peroxisome proliferator-activated receptor g (Pparg; B), adiponectin (Adipoq; C), lipoprotein lipase (Lpl; D), and uncoupling protein 1 (Ucp1; E) in PVAT of flox and HBK mice. (n = 3, unpaired Student’s t test, *P < 0.05). HBK, hepatocyte-specific Bmal1 knockout; PVAT, perivascular adipose tissue; RT-PCR, real-time polymerase chain reaction.