Table 2.

Food intake, water intake, urine production, and urinary sodium excretion in flox and HBK mice

	Flox		HBK
	Inactive Period	Active Period	Inactive Period	Active Period
Food intake, g/12 h	0.5 ± 0.0	3.9 ± 0.1‡	0.6 ± 0.1	3.7 ± 0.1‡
Water intake, mL/12 h	0.9 ± 0.1	3.7 ± 0.1‡	0.9 ± 0.1	3.5 ± 0.1‡
Urine volume, mL/12 h	0.1 ± 0.1	0.9 ± 0.2‡	0.1 ± 0.0	0.7 ± 0.1‡
Sodium excretion, mEq/12 h	0.02 ± 0.01	0.12 ± 0.02‡	0.01 ± 0.00	0.10 ± 0.01‡

Values are presented as means ± SE; n = 4. Two-way repeated-measures ANOVA was used to compare time of day and genotype effects with Sidak’s post hoc test for multiple comparisons. Time of day had a significant effect on food and water intake, urine volume, and urinary sodium excretion in both flox and HBK mice. Symbols indicate statistically significant differences (P < 0.05) between inactive and active periods.

‡P < 0.05 inactive vs. active.

HBK, hepatocyte-specific Bmal1 knockout.