Skip to main content
. 2019 Mar 22;316(6):H1281–H1296. doi: 10.1152/ajpheart.00532.2017

Table 1.

Echocardiographic parameters of MK5+/+ and MK5+/− mice 1 wk post-MI

Sham
LAD
MK5+/+ MK5+/− MK5+/+ (n = 20) MK5+/− (n = 17)
n 14 8 20 17
R-R interval, ms 117 ± 4 117 ± 3 125 ± 6 121 ± 4
Dimensions/mass
    LVAWd, mm 0.786 ± 0.013 0.784 ± 0.019 0.576 ± 0.041 0.641 ± 0.049
    LVPWd, mm 0.723 ± 0.011 0.725 ± 0.018 0.773 ± 0.029 0.783 ± 0.045
    LVDd, mm 3.81 ± 0.07 4.00 ± 0.12 4.93 ± 0.12 4.61 ± 0.17§
    LVDs, mm 2.31 ± 0.06 2.53 ± 0.07 4.17 ± 0.18 3.75 ± 0.26*
    LV mass, mg 100 ± 3 110 ± 6 135 ± 6 127 ± 6
    LV mass/LVDd, mg/mm 26.4 ± 0.5 27.3 ± 0.8 27.3 ± 1.1 27.8 ± 1.1
    LVmass/BW, mg/g 3.88 ± 0.08 4.03 ± 0.19 5.44 ± 0.33 5.11 ± 0.30§
    LVDd/BW, mm/g 0.147 ± 0.002 0.148 ± 0.003 0.198 ± 0.009 0.186 ± 0.010§
Systolic function
    LVFS, % 39.4 ± 0.9 36.5 ± 1.6 16.1 ± 2.0 20.2 ± 3.0*
    LVEF, % 76.1 ± 1.1 72.7 ± 2.0 37.5 ± 4.0 44.5 ± 5.5*
    Lateral Sm, cm/s 2.73 ± 0.09 2.66 ± 0.11 1.84 ± 0.12 1.84 ± 0.13
    Septal Sm, cm/s 2.91 ± 0.16 2.80 ± 0.12 2.18 ± 0.11 2.16 ± 0.15§
    WMSI 1.000 ± 0.0 1.000 ± 0.0 1.86 ± 0.12 1.90 ± 0.15
Diastolic function
    E velocity, cm/s 84.9 ± 3.0 86.0 ± 3.6 83.2 ± 4.7 79.4 ± 3.8
    E DT, msec 38.1 ± 1.9 39.9 ± 2.2 30.2 ± 1.5* 28.1 ± 1.3
    E D rate, m/s2 22.4 ± 1.1 22.1 ± 1.4 28.2 ± 1.7§ 28.6 ± 1.4*
    S/D upper 0.534 ± 0.044 0.509 ± 0.020 0.421 ± 0.053 0.353 ± 0.067
    S/D lower 1.84 ± 0.09 2.03 ± 0.32 1.97 ± 0.20 2.06 ± 0.16
LV isovolumetric relaxation time
    IVRT, ms 7.81 ± 0.67 7.91 ± 0.70 8.53 ± 0.99 7.84 ± 0.81
    IVRTc 0.719 ± 0.059 0.730 ± 0.059 0.747 ± 0.065 0.706 ± 0.06
Myocardial performance index
    Global MPI, % 42.9 ± 3.0 42.3 ± 3.3 63.3 ± 4.2* 79.3 ± 8.0*

Values are means ± SE. E, early diastolic transmitral filling velocity; EDT, early diastolic transmitral filling deceleration time; ED rate, early diastolic transmitral filling deceleration rate; FS, fractional shortening; IVRT, isovolumic relaxation time; IVRTc, rate-corrected isovolumic relaxation time; LVAWd, left ventricular anterior wall end-diastolic thickness; LVDd, left ventricular end-diastolic diameter; LVEF, left ventricular ejection fraction; LVDs, left ventricular end-systolic diameter; LVPWd, LV posterior wall end diastolic thickness; MI, myocardial infarction; MK5, MAP kinase-activated protein kinase-5; MPI, myocardial performance index; S/D, pulmonary venous systolic wave/pulmonary venous early diastolic wave; Sm, peak systolic tissue velocity; WMSI, wall motion score index.

§

P < 0.05 vs. sham;

*

P < 0.01 vs. sham;

P < 0.001 vs. sham;

P < 0.0001 vs. sham.