Table 1.
Echocardiographic parameters of MK5+/+ and MK5+/− mice 1 wk post-MI
| Sham |
LAD |
|||
|---|---|---|---|---|
| MK5+/+ | MK5+/− | MK5+/+ (n = 20) | MK5+/− (n = 17) | |
| n | 14 | 8 | 20 | 17 |
| R-R interval, ms | 117 ± 4 | 117 ± 3 | 125 ± 6 | 121 ± 4 |
| Dimensions/mass | ||||
| LVAWd, mm | 0.786 ± 0.013 | 0.784 ± 0.019 | 0.576 ± 0.041‡ | 0.641 ± 0.049 |
| LVPWd, mm | 0.723 ± 0.011 | 0.725 ± 0.018 | 0.773 ± 0.029 | 0.783 ± 0.045 |
| LVDd, mm | 3.81 ± 0.07 | 4.00 ± 0.12 | 4.93 ± 0.12† | 4.61 ± 0.17§ |
| LVDs, mm | 2.31 ± 0.06 | 2.53 ± 0.07 | 4.17 ± 0.18† | 3.75 ± 0.26* |
| LV mass, mg | 100 ± 3 | 110 ± 6 | 135 ± 6‡ | 127 ± 6 |
| LV mass/LVDd, mg/mm | 26.4 ± 0.5 | 27.3 ± 0.8 | 27.3 ± 1.1 | 27.8 ± 1.1 |
| LVmass/BW, mg/g | 3.88 ± 0.08 | 4.03 ± 0.19 | 5.44 ± 0.33‡ | 5.11 ± 0.30§ |
| LVDd/BW, mm/g | 0.147 ± 0.002 | 0.148 ± 0.003 | 0.198 ± 0.009† | 0.186 ± 0.010§ |
| Systolic function | ||||
| LVFS, % | 39.4 ± 0.9 | 36.5 ± 1.6 | 16.1 ± 2.0† | 20.2 ± 3.0* |
| LVEF, % | 76.1 ± 1.1 | 72.7 ± 2.0 | 37.5 ± 4.0† | 44.5 ± 5.5* |
| Lateral Sm, cm/s | 2.73 ± 0.09 | 2.66 ± 0.11 | 1.84 ± 0.12† | 1.84 ± 0.13‡ |
| Septal Sm, cm/s | 2.91 ± 0.16 | 2.80 ± 0.12 | 2.18 ± 0.11‡ | 2.16 ± 0.15§ |
| WMSI | 1.000 ± 0.0 | 1.000 ± 0.0 | 1.86 ± 0.12 | 1.90 ± 0.15 |
| Diastolic function | ||||
| E velocity, cm/s | 84.9 ± 3.0 | 86.0 ± 3.6 | 83.2 ± 4.7 | 79.4 ± 3.8 |
| E DT, msec | 38.1 ± 1.9 | 39.9 ± 2.2 | 30.2 ± 1.5* | 28.1 ± 1.3† |
| E D rate, m/s2 | 22.4 ± 1.1 | 22.1 ± 1.4 | 28.2 ± 1.7§ | 28.6 ± 1.4* |
| S/D upper | 0.534 ± 0.044 | 0.509 ± 0.020 | 0.421 ± 0.053 | 0.353 ± 0.067 |
| S/D lower | 1.84 ± 0.09 | 2.03 ± 0.32 | 1.97 ± 0.20 | 2.06 ± 0.16 |
| LV isovolumetric relaxation time | ||||
| IVRT, ms | 7.81 ± 0.67 | 7.91 ± 0.70 | 8.53 ± 0.99 | 7.84 ± 0.81 |
| IVRTc | 0.719 ± 0.059 | 0.730 ± 0.059 | 0.747 ± 0.065 | 0.706 ± 0.06 |
| Myocardial performance index | ||||
| Global MPI, % | 42.9 ± 3.0 | 42.3 ± 3.3 | 63.3 ± 4.2* | 79.3 ± 8.0* |
Values are means ± SE. E, early diastolic transmitral filling velocity; EDT, early diastolic transmitral filling deceleration time; ED rate, early diastolic transmitral filling deceleration rate; FS, fractional shortening; IVRT, isovolumic relaxation time; IVRTc, rate-corrected isovolumic relaxation time; LVAWd, left ventricular anterior wall end-diastolic thickness; LVDd, left ventricular end-diastolic diameter; LVEF, left ventricular ejection fraction; LVDs, left ventricular end-systolic diameter; LVPWd, LV posterior wall end diastolic thickness; MI, myocardial infarction; MK5, MAP kinase-activated protein kinase-5; MPI, myocardial performance index; S/D, pulmonary venous systolic wave/pulmonary venous early diastolic wave; Sm, peak systolic tissue velocity; WMSI, wall motion score index.
P < 0.05 vs. sham;
P < 0.01 vs. sham;
P < 0.001 vs. sham;
P < 0.0001 vs. sham.