Table 2.

Effect of reduced MK5 expression on cell density

	MK5+/+	MK5+/−	MK5−/−	scRNA	siRNA
n	3	3	3	3	3
Control	1.13 ± 0.05	1.13 ± 0.04	1.01 ± 0.02	1.09 ± 0.01	1.07 ± 0.02
ANG II	1.25 ± 0.03	1.43 ± 0.08	1.13 ± 0.06c	1.29 ± 0.04	1.14 ± 0.02e
Serum	1.39 ± 0.05	1.41 ± 0.06	1.19 ± 0.01a,b	1.57 ± 0.07	1.33 ± 0.03f
Serum + ANG II	1.34 ± 0.06	1.54 ± 0.08a	1.13 ± 0.05a,d

Values are means ± SE; n = no. of independent fibroblast preparations. ANG II, angiotensin II; MK5, MAP kinase-activated protein kinase-5; scRNA, scrambled RNA; siRNA, small interfering RNA.

^aP < 0.05 vs. MK5^+/+;

^bP < 0.05 vs. MK5^+/−;

^cP < 0.01 vs. MK5^+/−;

^dP < 0.0001 vs. MK5^+/−;

^eP < 0.05 vs.scRNA;

^fP < 0.01 vs. scRNA.