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. 2021 Apr 21;320(6):L1158–L1168. doi: 10.1152/ajplung.00299.2020

Figure 1.

Figure 1.

Abnormal lung development in mesenchyme-specific transforming growth factor-β (TGF-β) receptor 2 gene (Tgfbr2) conditional knockout (CKO) mice. A: body sizes of newborn Tgfbr2 CKO and wild-type (WT) mice are comparable. Bluish discoloration was apparent in Tgfbr2 CKO mice. B: lungs isolated from Tgfbr2 CKO and WT fetuses and neonates are compared side by side under dissecting microscope. Scale bar: 1 mm. C: whole mount anti-Cdh1 immunofluorescence staining of embryonic day (E) 14 lungs highlights airway epithelial branching structures. Different branching patterns between Tgfbr2 CKO and WT are marked by arrows. Scale bar: 0.4 mm. D: the numbers of left lung terminal branches between E14 Tgfbr2 CKO and WT lungs are compared. *P < 0.05 (n = 6, no. of mice).