Table 2.
Effect of Val and Sac/Val on physical and biochemical characteristics in nondiabetic (C57BL/6) and diabetic (KKAy) mice
| C57BL/6 | C57BL/6 + Sac/Val | C57BL/6 + Val | KKAy | KKAy + Sac/Val | KKAy + Val | |
|---|---|---|---|---|---|---|
| Body weight, g | 27.3 ± 0.9 | 30.1 ± 0.9 | 30.9 ± 0.9 | 43.5 ± 0.9a | 42.1 ± 0.9 | 43.3 ± 0.9 |
| Food intake, g | 3.75 ± 0.29 | 3.6 ± 0.29 | 3.56 ± 0.29 | 6.3 ± 0.29a | 6.2 ± 0.29 | 5.9 ± 0.29 |
| Kidney weight/body weight, mg/g | 0.01 ± 0.007 | 0.01 ± 0.007 | 0.01 ± 0.007 | 0.016 ± 0.007b | 0.013 ± 0.007c | 0.014 ± 0.007 |
| Systolic blood pressure, mmHg | 112.4 ± 4.3 | 110.8 ± 4.3 | 113.4 ± 4.3 | 109.3 ± 4.3 | 92.6 ± 4.3d | 94.4 ± 4.3d |
| Glucose, mg/dL | 183.8 ± 27.8 | 161.3 ± 27.8 | 174.2 ± 27.8 | 325.5 ± 27.8a | 185.7 ± 28.5e,f | 278.8 ± 28.5 |
| Blood urea nitrogen, mg/dL | 44.9 ± 7.8 | 45.8 ± 7.8 | 46.1 ± 7.8 | 87.1 ± 7.8a | 66.8 ± 7.8g,f | 91.02 ± 7.8 |
| Triglycerides, mg/dL | 48.4 ± 15.9 | 42.6 ± 15.9 | 49.7 ± 15.9 | 244.1 ± 15.9a | 142.8 ± 15.9d,f | 192 ± 15.9c |
| Cholesterol, mg/dL | 114.9 ± 8.9 | 114.5 ± 8.9 | 114.1 ± 8.9 | 172 ± 8.9a | 136.2 ± 8.9d | 154.1 ± 8.9 |
All data analyses are presented as means ± SE for n = 9 or 10 mice in each group. Sac, sacubitril; Val, valsartan. aP < 0.0001 vs. C57BL6/J; bP < 0.001 vs. C57BL6/J; cP < 0.01 vs. KKAy; dP < 0.001 vs. KKAy; eP < 0.0001 vs. KKAy; fP < 0.01 vs. KKAy + Val; gP < 0.05 vs. KKAy.