Figure 3.

Deletion of Kir5.1 abolishes the effect of dietary Na⁺ intake on basolateral K⁺ conductance. A: set of recordings showing Ba²⁺-sensitive K⁺ currents measured with the step protocol from −100 to 60 mV in the early distal convoluted tubule (DCT1) of wild-type (WT) and Kir5.1 knockout (KO) mice on low-sodium (LS), normal-sodium (NS), and high-sodium (HS) diets for 7 days, respectively. B: scatter graph summarizing values measured at −60 mV in the DCT1 of WT and Kir5.1 KO mice on different Na⁺ diets with whole cell recordings. Mean values and SEs are shown on the left of each column. *Significant difference as determined by two-way ANOVA. Data from male and female mice are indicated by triangles and circles, respectively.