Figure 5.

Input resistance in the rectified range varied by sex and perinatal exposure to estradiol. A: voltage response of a MSN to a series of negative current injections, recorded from a male with perinatal exposure to vehicle. “−76 mV” indicates resting membrane potential. B: injected negative current to steady-stage voltage deflection curve (IV curve). C: inward rectification was increased in MSNs recorded from females with perinatal exposure to vehicle compared to females with perinatal exposure to estradiol and males with perinatal exposure to vehicle. Inward rectification was decreased MSNs recorded from females with perinatal exposure to estradiol compared to males with perinatal exposure to estradiol. D: percent inward rectification was decreased in MSNs recorded from females with perinatal exposure to vehicle compared to females with perinatal exposure to estradiol. Percent inward rectification was increased in MSNs recorded from females with perinatal exposure to estradiol compared to males with perinatal exposure to estradiol. Note that decreased percent inward rectification values typically correspond with increased inward rectification values. MSN, medium spiny neuron. #P = 0.0733; *P < 0.05; **P < 0.01.