Table 2.
Caudate-putamen medium spiny neuron electrophysiological properties from females exposed to PPT, DPN, or G1 and females and males exposed to vehicle during the perinatal period
| Property | Vehicle | PPT | DPN | G1 | Statistics (F, P) |
|---|---|---|---|---|---|
| Resting membrane potential, mV | F: −82.8 ± 1.7 (24) | −85.3 ± 1.3 (31) | −83.4 ± 1.2 (22) | −86.5.9 ± 1.5 (30) | 1.093 |
| M: −84.2 ± 1.3 (28) | 0.3628 | ||||
| Input resistance, MΩ | F: 260.2 ± 26.9 (24) | 287.1 ± 17.4 (31) | 261.9 ± 18.7 (22) | 232.9 ± 13.0 (30) | 1.395 |
| M: 245.2 ± 15.3 (28) | 0.2392 | ||||
| Rectified range input resistance, MΩ | F: 200.1 ± 13.7 (24) | 224.8 ± 11.5 (31) | 229.5 ± 15.3 (22) | 181.9 ± 9.9 (30) | 2.484 |
| M: 209.6 ± 12.2 (28) | 0.0468 | ||||
| Inward rectification, MΩ | F: 62.7 ± 14.8 (24) | 62.3 ± 7.3 (31) | 32.4 ± 5.9 (22) | 51.0 ± 5.6 (30) | 2.989 |
| M: 35.5 ± 4.7 (28) | 0.0212 | ||||
| % Inward rectification, % | F: 82.2 ± 2.8 (24) | 79.9 ± 1.5 (31) | 88.6 ± 1.7 (22) | 79.2 ± 1.8 (30) | 4.789 |
| M: 86.5 ± 1.5 (28) | 0.0012 | ||||
| Time constant of the membrane, ms | F: 16.6 ± 2.5 (24) | 18.0 ± 1.1 (31) | 12.8 ± 0.8 (22) | 15.7 ± 1.2 (30) | 2.425 |
| M: 13.2 ± 1.0 (28) | 0.0513 | ||||
| Capacitance, pF | F: 61.6 ± 4.8 (24) | 66.2 ± 4.2 (31) | 52.3 ± 4.9 (22) | 70.5 ± 5.3 (30) | 2.900 |
| M: 54.9 ± 3.1 (28) | 0.0245 | ||||
| Rheobase, pA | F: 101.9 ± 12.8 (24) | 95.5 ± 7.9 (31) | 135.2 ± 15.1 (22) | 99.2 ± 7.5 (30) | 2.077 |
| M: 111.7 ± 10.5 (28) | 0.0875 | ||||
| Delay to first AP, ms | F: 310.1 ± 27.0 (24) | 381.5 ± 21.4 (31) | 363.3 ± 20.5 (22) | 365.5 ± 18.3 (30) | 1.661 |
| M: 344.1 ± 17.0 (28) | 0.1629 | ||||
| AP threshold, mV | F: −48.4 ± 1.7 (24) | −50.6 ± 1.6 (31) | −42.2 ± 2.3 (22) | −50.1 ± 1.5 (30) | 3.424 |
| M: −45.8 ± 2.0 (28) | 0.0107 | ||||
| AP width at half-peak amplitude, ms | F: 2.6 ± 0.2 (24) | 3.1 ± 0.1 (31) | 2.9 ± 0.1 (22) | 2.4 ± 0.1 (30) | 4.643 |
| M: 3.0 ± 0.2 (28) | 0.0016 | ||||
| AHP peak amplitude, mV | F: −7.6 ± 0.5 (24) | −7.2 ± 0.4 (31) | −6.9 ± 0.5 (22) | −7.4 ± 0.4 (30) | 1.500 |
| M: −8.4 ± 0.4 (28) | 0.2059 | ||||
| AHP time to peak, ms | F: 33.5 ± 3.4 (24) | 36.0 ± 3.0 (31) | 29.8 ± 2.0 (22) | 29.5 ± 1.9 (30) | 2.003 |
| M: 37.5 ± 2.3 (28) | 0.0979 | ||||
| FI slope, Hz/nA | F: 207.1 ± 24.2 (24) | 178.9 ± 6.9 (31) | 171.0 ± 14.2 (22) | 224.8 ± 19.9 (30) | 3.181 |
| M: 157.9 ± 8.5 (28) | 0.0157 |
Electrophysiological properties recorded from caudate-putamen MSNs from prepubertal female rats exposed to vehicle, PPT, DPN, or G1 and males exposed to vehicle during the perinatal period. Values are means ± SE. Numbers in parentheses indicate the number of neurons in each group (experimental n). Statistics column lists F and P values for one-way ANOVA analysis. Bold font indicates statistical significance. AHP, afterhyperpolarization; AP, action potential; F, female; FI, evoked firing rate-to-positive current curve; M, male; mEPSC, miniature excitatory postsynaptic current.