Table 3.
Caudate-putamen medium spiny neuron electrophysiological properties from males exposed to PPT, DPN, or G1 and females and males exposed to vehicle during the perinatal developmental period
| Property | Vehicle | PPT | DPN | G1 | Statistics (F, P) |
|---|---|---|---|---|---|
| Resting membrane potential, mV | F: −82.8 ± 1.7 (24) | −86.1 ± 1.8 (25) | −83.5 ± 2.0 (26) | −81.6 ± 3.0 (30) | 0.740 |
| M: −84.2 ± 1.3 (28) | 0.5665 | ||||
| Input resistance, MΩ | F: 260.2 ± 26.9 (24) | 279.3 ± 25.8 (25) | 270.9 ± 21.6 (26) | 247.5 ± 28.0 (17) | 0.405 |
| M: 245.2 ± 15.3 (28) | 0.8046 | ||||
| Rectified range input resistance, MΩ | F: 200.1 ± 13.7 (24) | 219.8 ± 12.5 (25) | 226.6 ± 17.5 (26) | 208.6 ± 19.4 (17) | 0.498 |
| M: 209.6 ± 12.2 (28) | 0.7371 | ||||
| Inward rectification, MΩ | F: 62.7 ± 14.8 (24) | 59.5 ± 16.4 (25) | 44.2 ± 7.0 (26) | 39.0 ± 11.9 (17) | 1.138 |
| M: 35.5 ± 4.7 (28) | 0.3423 | ||||
| % Inward rectification, % | F: 82.2 ± 2.8 (24) | 82.8 ± 2.5 (25) | 84.7 ± 2.1 (26) | 86.2 ± 2.0 (17) | 0.769 |
| M: 86.5 ± 1.5 (28) | 0.5474 | ||||
| Time constant of the membrane, ms | F: 16.6 ± 2.5 (24) | 14.4 ± 1.5 (25) | 15.0 ± 1.3 (26) | 14.0 ± 1.7 (17) | 0.591 |
| M: 13.2 ± 1.0 (28) | 0.6699 | ||||
| Capacitance, pF | F: 61.6 ± 4.8 (24) | 52.4 ± 2.7 (25) | 58.6 ± 5.3 (26) | 59.7 ± 5.4 (17) | 0.673 |
| M: 54.9 ± 3.1 (28) | 0.6117 | ||||
| Rheobase, pA | F: 101.9 ± 12.8 (24) | 107.1 ± 11.9 (25) | 116.7 ± 13.9 (26) | 130.2 ± 12.5 (17) | 0.623 |
| M: 111.7 ± 10.5 (28) | 0.6473 | ||||
| Delay to first AP, ms | F: 310.1 ± 27.0 (24) | 327.3 ± 21.0 (25) | 380.0 ± 21.0 (26) | 388.1 ± 28.9 (17) | 2.049 |
| M: 344.1 ± 17.0 (28) | 0.0922 | ||||
| AP threshold, mV | F: −48.4 ± 1.7 (24) | −45.8 ± 2.0 (25) | −47.3 ± 1.8 (26) | −47.0 ± 2.2 (17) | 0.294 |
| M: −45.8 ± 2.0 (28) | 0.8817 | ||||
| AP width at half-peak amplitude, ms | F: 2.6 ± 0.2 (24) | 2.6 ± 0.1 (25) | 2.7 ± 0.2 (26) | 2.6 ± 0.2 (17) | 0.962 |
| M: 3.0 ± 0.2 (28) | 0.4312 | ||||
| AHP peak amplitude, mV | F: −7.6 ± 0.5 (24) | −6.9 ± 0.3 (25) | −7.5 ± 0.5 (26) | −7.2 ± 0.3 (17) | 1.797 |
| M:−8.4 ± 0.4 (28) | 0.1341 | ||||
| AHP time to peak, ms | F: 33.5 ± 3.4 (24) | 32.1 ± 2.3 (25) | 33.0 ± 1.8 (26) | 33.4 ± 3.0 (17) | 0.749 |
| M: 37.5 ± 2.3 (28) | 0.5606 | ||||
| FI slope, Hz/nA | F: 207.1 ± 24.2 (24) | 229.2 ± 26.0 (25) | 185.7 ± 11.0 (26) | 186.4 ± 10.1 (17) | 2.409 |
| M: 157.9 ± 8.5 (28) | 0.0533 |
Electrophysiological properties recorded from caudate-putamen MSNs from prepubertal male rats exposed to vehicle, PPT, DPN, or G1 and females exposed to vehicle during the perinatal period. Values are means ± SE. Numbers in parentheses indicate the number of neurons in each group (experimental n). Statistics column lists F and P values for one-way ANOVA analysis. AHP, afterhyperpolarization; AP, action potential; F, female; FI, evoked firing rate-to-positive current curve; M, male; mEPSC, miniature excitatory postsynaptic current.