Figure 7.

Spatiotemporal causal map of behavioral impact

(A) Spatiotemporally specific optogenetic inactivation in VGAT-ChR2 transgenic mice. Blue shaded areas represent inactivation windows across the trial timeline.

(B) Behavioral impact of optogenetic inactivation across time windows for each brain region (mean ± SEM). For each area, hit rate (black) and false-alarm rate (red) are plotted for light-off (off), baseline (B), whisker (W), delay (D), and response (R) windows. Asterisks represent significant difference comparing hit (black) or false alarm (red) in light trials versus light-off trials (n = 9 mice; ^∗p < 0.05; Wilcoxon signed-rank test, Bonferroni correction for multiple comparison).

(C) Spatiotemporal map of behavioral impact of focal inactivation in go (top) and no-go trials (bottom). Circles represent different cortical regions labeled on the schematic in (A); color shows change in lick probability, and circle size shows the p value of the significance test comparing light trials versus light-off trials (n = 9 mice, Wilcoxon signed-rank test, Bonferroni correction for multiple comparison).

See also Figure S8.